Prolactin regulates ZnT2 transcription through the JAK2‐STAT5 signaling pathway

Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.

The zinc transporter ZnT2 (SLC30A2) plays an important role in zinc secretion into milk during lactation. The physiological process of mammary gland secretion is regulated through complex integration of multiple lactogenic hormones. Prolactin plays a primary role in this regulation through the activation of various signaling cascades including Jak2/STAT5, mitogen-activated protein kinase (MAPK)...

miR-320 regulates inflammation in EAE through interference with TGF-β signaling pathway

Background: MicroRNAs are small noncoding RNAs that regulate gene expression and involve in many cellular and physiological mechanisems. Recent studies have revealed that dysregulation of microRNAs might contribute to autoimmune disorders such as multiple sclerosis. Based on these findings, we examined the potential role of miR-320 isoforms, miR-320-3p and miR-320-5p, in the context of autoimmu...

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway

Prolactin regulates ZnT 2 expression through the JAK 2 / STAT 5 1 signaling pathway in mammary cells

28 The zinc transporter ZnT2 (SLC30A2) plays an important role in zinc secretion into milk during 29 lactation. The physiological process of mammary gland secretion is regulated through complex 30 integration of multiple lactogenic hormones. Prolactin plays a primary role in this regulation 31 through the activation of various signaling cascades including Jak2/STAT5, MAPK, p38 and 32 PI3K. The ...

AcSDKP Regulates Cell Proliferation through the PI3KCA/Akt Signaling Pathway

The natural tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) is generated from the N-terminus of thymosin-β4 through enzymatic cleavage by prolyl oligopeptidase (POP). AcSDKP regulation of proliferation of different cells is implicated in hematopoiesis and angiogenesis. This tetrapeptide present in almost all cells was recently detected at elevated concentrations in neoplastic diseases. However, ...